A helpful list of the 11 biggest questions about dark matter starts with this:
Originally, some scientists conjectured that the missing mass in the universe was made up of small faint stars and black holes, though detailed observations have not turned up nearly enough such objects to account for dark matter’s influence, as physicist Don Lincoln of the U.S. Department of Energy’s Fermilab previously wrote for Live Science. The current leading contender for dark matter’s mantle is a hypothetical particle called a Weakly Interacting Massive Particle, or WIMP, which would behave sort of like a neutron except would be between 10 and 100 times heavier than a proton, as Lincoln wrote. Yet, this conjecture has only led to more questions… Adam Mann, “The 11 Biggest Unanswered Questions About Dark Matter” at LiveScience
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See also: Discover: Even the best dark matter theories are crumbling
Researcher: The search for dark matter has become a “quagmire of confirmation bias” So many research areas in science today are hitting hard barriers that it is reasonable to think that we are missing something.
Physicists devise test to find out if dark matter really exists
Largest particle detector draws a blank on dark matter
What if dark matter just doesn’t stick to the rules?
A proposed dark matter solution makes gravity an illusion
Proposed dark matter solution: “Gravity is not a fundamental governance of our universe, but a reaction to the makeup of a given environment.”