Cell biology Genetics Intelligent Design

What happens when DNA snaps?

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Cells have self-repairing suspension bridges:

Cells face that kind of challenge every day, but they are well equipped to handle it. When both DNA strands break (the “double-stranded break” crisis, or DSB), a cell can die. Molecular machines fly into action as the strands flail about, threatening genomic catastrophe. The repair crew has an additional problem: unlike the bridge cable, the DNA strand is made up of a sequence of code that needs to match what was there before the DSB. In a process called homologous recombination, the machinery searches for a template to rebuild the broken sequence. Researchers at Uppsala University know that this process is mostly “well described in the literature.”

However, the description usually disregards the daunting task of finding the matching template among all the other genome sequences. The chromosome is a complex structure with several million base pairs of genetic code and it is quite clear that simple diffusion in 3D would not be sufficiently fast by a long shot. But then, how is it done? This has been the mystery of homologous recombination for 50 years. From previous studies, it is clear that the molecule RecA is involved and important in the search process, but, up until now, this has been the limit of our understanding of this process. [Emphasis added.]

Even a simple bacterium knows a trick to make the search easier. It reduces the search from a 3D problem to a 2D problem. With that shortcut, the cell reduces the time to repair down to 15 minutes on average. The Uppsala group, using CRISPR and fluorescent tags, watched the RecA proteins in real time. They published their findings in Nature.

Evolution News, “Tricks of the Cell Trade” at Evolution News and Science Today (September 27, 2021)

After a while, you know it all didn’t “just happen” and the Voice of Science isn;t helping much by claiming that that must beso.

9 Replies to “What happens when DNA snaps?

  1. 1
    ram says:

    I like to encourage people to roast coffee at home. Get a cheap $100 roaster on Amazon and learn how to do a decent roast. (Tons of videos on Youtube. You’ll be making a decent roast in no time.) My point is, I don’t think anyone knows how to think clearly until they’ve learnt how to roast a few beans. It will sharpen up your thinking. Very practical, and immensely pleasurable (if you like coffee.)

    God made coffee for a reason. Just do it.

  2. 2
    AaronS1978 says:

    Bot or Troll
    You decide

  3. 3
    martin_r says:

    @2 bot or troll or a Darwinist

  4. 4
    martin_r says:

    catastrophic DNA double strand breaks….

    Molecular machines fly into action as the strands flail about, threatening genomic catastrophe.

    a typical Darwinian way how to put things “molecular machines fly into action” … problem solved …

    i, as an engineer, was asking myself:

    how on Earth the cell knows, that there is a double strand break ??? (so the DNA repair machines can fly into action)

    So i had a closer look at this deadly problem, and found out, that there are DNA damage sensors … …. such a coincidence … Darwinists think, that things repair just so, by itself … that repair machines “fly into action” because Darwinists wish so …

    OF COURSE NOT!

    I, AS AN ENGINEER, AM LETTING YOU KNOW, THAT YOU NEED TO KNOW WHAT, WHEN AND HOW TO, IN ORDER TO REPAIR SOMETHING! (and eventually to make sure, you did it right)

    And this is exactly the way it works inside the cell….

    HOW ON EARTH COULD AN BLIND, UNGUIDED, NATURAL PROCESS WHERE IS NO FORESIGHT design SENSORS ????? WHY ON EARTH THERE SHOULD BE ANY SENSORS IN THE FIRST PLACE ??? and i can assure you, in living things, there are sensors everywhere ….

    IF SENSORS ARE NOT THE ULTIMATE EVIDENCE OF DESIGNED LIFE, THEN I DON’T KNOW WHAT ELSE IS ….

    WHEN THIS DARWINIAN CRAZINESS WILL END ????

    few quotes from a mainstream paper:

    SIRT6 is a DNA double-strand break sensor

    DNA double-strand breaks (DSB) are the most deleterious type of DNA damage. In this work, we show that SIRT6 directly recognizes DNA damage through a tunnel-like structure that has high affinity for DSB. SIRT6 relocates to sites of damage independently of signaling and known sensors. It activates downstream signaling for DSB repair by triggering ATM recruitment, H2AX phosphorylation and the recruitment of proteins of the homologous recombination and non-homologous end joining pathways. Our findings indicate that SIRT6 plays a previously uncharacterized role as a DNA damage sensor, a critical factor in initiating the DNA damage response (DDR). Moreover, other Sirtuins share some DSB-binding capacity and DDR activation. SIRT6 activates the DDR before the repair pathway is chosen, and prevents genomic instability. Our findings place SIRT6 as a sensor of DSB, and pave the road to dissecting the contributions of distinct DSB sensors in downstream signaling.

    https://elifesciences.org/articles/51636

  5. 5
    jerry says:

    WHEN THIS DARWINIAN CRAZINESS WILL END

    When ID supports what Darwin discovered.

    He discovered something amazing but it had nothing to do with Evolution. It’s obvious. Accept it and move on.

    The fixation on DNA is the problem. Unbelievable process but all it does is make proteins. A fraction of what is life.

    Smell the Coffee

  6. 6
    Hanks says:

    @Martin_r: You should write a book .

  7. 7
    Silver Asiatic says:

    martin_r

    HOW ON EARTH COULD AN BLIND, UNGUIDED, NATURAL PROCESS WHERE IS NO FORESIGHT design SENSORS ????? WHY ON EARTH THERE SHOULD BE ANY SENSORS IN THE FIRST PLACE ???

    Evolutionists do not ask these kinds of questions. They do not take the time to think about things – like what a blind, unintelligent, unguided process actually is – and then what could it do?
    They also don’t think about foresight – future planning.
    The term “evolution” covers any possible thing that is found in nature. “Sensors evolved” is all that is required.
    The answer is to try to get evolutionists to slow down, take some time and think about what they’re actually saying.

  8. 8
    martin_r says:

    Hanks @6

    i am thinking of it … (or at least some youtube presentation)

    PS:
    i run a blog … have a look at https://www.stuffhappens.info

  9. 9
    ram says:

    AaronS1978,

    Neither bot nor troll. Just a home-roasting coffee evangelist, trying to spread greater happiness to the world.

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