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Dr Zelenko on Israel National News, May 21, 2020 — forthcoming paper ~ two weeks?

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Dr Zelenko expects to be in publication along with some German colleagues, in about two weeks. In the following video (pardon quality issues):

. . . he asks, in effect, isn’t it standard to treat a disease as early as possible, so why the strange difference here? He makes a comparison to how a fire can flash over into a much more dangerous stage and notes how much easier it is to hit it while it is small. He expresses a measure of anger with medical and political establishments, /do allow for that.

He identifies that by the time people are at a Doctor’s office they are likely to be about day 5 in the disease process, on the verge of an explosion in viral load with attendant damage to the body.

He estimates turnaround time at about 3 days on tests, thus if you wait you likely have had serious damage due to explosion in viral load with attendant cell destruction to produce those viruses; linked doubtless, is immune response which can spin out of control in a potentially fatal cytokine storm.

He points to manageable toxicity and safety then suggests, go on the drug cocktail, then pull back if there is no need.

An implication of his discussion is what we may call the U-model of such a disease as this. As came up in a current UD thread:

The idea is that a fast-mover disease like this triggers a U-shaped trend (with a potentially catastrophic descending arm), where the crisis is the bend. Those who fail to make it, unfortunately die . . . a reverse J as the rising arm has been frustrated. Recovery then takes an onward period so recovery statistics lag death statistics, part of the epidemiologist’s headaches. Of course, relapses can move us to a W . . . double U . . . etc. So, we have a simple descriptive model of the trend of such an illness. [This is similar to the plucking model of recession in economics.] The stitch in time factor is, to hit the process early in the descending arm, so the U is shallow; you will probably recall the question of building up one’s “resistance” to colds, Flu and the like. In the context of Ivermectin, its preliminary indication is that it can help to pluck back up from further down the descending arm. And of course hospitalisation is an index of being fairly far down the arm, ICU being a yet worse sign. Intubation and Ventilation are grim signs.

While we wait on his announced publication, we may wish to discuss. END

PS: An interesting second vid comes from India, courtesy Tech for Luddites:

https://www.youtube.com/watch?v=H8HtWHAr9rI

PPS: Here is the screen clip, June 3rd:

Comments
Egypt’s coronavirus infection numbers fall short of accuracy, the country’s higher education and scientific research minister said on Monday. The country's real tally of infections is five times higher than data announced by the country’s Health Ministry, while the actual number of deaths is 10 times higher than official figures, local media quoted Khalid Atef Abdul Ghaffar as saying. Egypt’s total number of coronavirus cases has surpassed 117,000, while the number of virus-linked deaths has exceeded 9,000, Ghaffar said. Egypt’s Health Ministry reported 46 new deaths on Monday, bringing the country’s official total to 959. The ministry said in a statement that there were a total of 24,985 confirmed cases in the country. https://www.aa.com.tr/en/health/-egypt-s-real-virus-figures-higher-than-official-ones/1861400rhampton7
June 1, 2020
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Is Sweden doing badly because it apparently bungled treatment in elderly care facilities. https://bit.ly/2BgvmyC
Upwards of 70 percent of the COVID-19 death toll in Sweden has been people in elderly care services (as of mid-May 2020). We summarize the COVID-19 tragedy in elderly care in Sweden, particularly in the City of Stockholm. We explain the institutional structure of elderly care administration and service provision. Those who died of COVID-19 in Stockholm’s nursing homes had a life-remaining median somewhere in the range of 5 to 9 months. Having contextualized the COVID-19 problem in City of Stockholm, we present an interview of Barbro Karlsson, who works at the administrative heart of the Stockholm elderly care system. Her institutional knowledge and sentiment offer great insight into the concrete problems and challenges. There are really two sides to the elderly care COVID-19 challenge: The vulnerability and frailty of those in nursing homes and the problem of nosocomial infection—that is, infection caused by contact with others involved in the elderly care experience. The problem calls for targeted solutions by those close to the vulnerable individuals.
They apparently did the same thing as Cuomo and sent infected patients back into elderly care facilities. There was also a policy of no treatment in hospitals even with antibiotics for things like pneumonia but just palliative care. Is it possible that the Sweden model has been successful but medical care was extremely inadequate especially for the elderly.jerry
June 1, 2020
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Thousands of Israeli pupils and staff were sent home Monday into quarantine as new cases of coronavirus were found at schools throughout the country. The Hadera Municipality announced the closure of a high school with some 2,200 students after a seventh grade girl was tested positive for COVID-19, Hebrew-language outlet Ynet reported. Link brokenrhampton7
June 1, 2020
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Sweden will launch a probe into the country’s handling of the coronavirus after controversially refusing lockdown measures, its prime minister announced Monday. Prime Minister Stefan Lofven said a commission would be appointed before the end of summer to look back at the decision to keep most schools, restaurants and businesses open after the virus reached the nation. “We need to take an overall approach to see how it has worked at national, regional and local levels,” Lofven told Swedish newspaper Aftonbladet. “We will make a decision for a commission before the summer.” https://nypost.com/2020/06/01/sweden-to-launch-coronavirus-probe-after-refusing-to-lock-down/rhampton7
June 1, 2020
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Russia — along with Nigeria and Spain, among other countries — has stood by its use of the drug, which the Health Ministry recommends as both a treatment for coronavirus patients and a preventative measure for the over-60s and anyone who has been in contact with the virus or spends time around patients. Not all of Russia’s medical experts agree. “We should abolish the use of this tool to combat the coronavirus in Russia,” Vadim Pokrovsky, head of the Federal Center for Fighting AIDS, told the online Gazeta.ru outlet last Tuesday. The expert, who has years of experience using experimental drugs in treating confounding diseases, explained that the anti-inflammatory effects researchers had banked on hadn’t panned out, while the negative side effects outweighed any benefits. In interviews with over a dozen medical professionals working with coronavirus patients around Russia, The Moscow Times found that many — including entire hospitals — agree with Pokrovsky and are ignoring official guidelines. Andrei Zaytsev, the chief pulmonologist for the Defense Ministry, ruled out the use of hydroxychloroquine in his own Facebook post. “Our already low expectations regarding the possibilities of ‘antiviral therapy’ using lopinavir/ritonavir” — normally used for treating HIV — “and hydroxychloroquine did not materialize,” he wrote. https://www.themoscowtimes.com/2020/06/01/as-russian-officials-back-hydroxychloroquine-doctors-take-matters-into-their-own-hands-a70435rhampton7
June 1, 2020
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H'mm: GT Result from what looks like Young Africa: >>Health Hydroxychloroquine still popular in Africa, despite controversy May 30, 2020 at 5:28 pm | By Marième Soumaré Updated on May 30, 2020 at 5:48 p.m. A coronavirus screening campaign in Johannesburg, South Africa, May 8, 2020. Adopted in Africa since the start of the pandemic, the famous "Raoult protocol", mixing chloroquine and azithromycin, continues to be used in many countries, despite warnings from WHO following the study published by "The Lancet ”. The response will not be long in coming. Less than a week after the publication in the prestigious scientific journal The Lancet of a study questioning the efficacy of hydroxychloroquine against the coronavirus, the infectiologist Didier Raoult published new results to defend his treatment. "Early diagnosis, early isolation and early treatment with at least three days of HCQ-AZ provide significantly better clinical outcome and contagiousness in patients with Covid-19 than other treatments," concludes l 'study. It is based on the clinical management of 3,737 patients, the majority (81.7%) of whom have been treated with the famous HCQ-AZ process: the hydroxychloroquine-azithromycin combination.>>kairosfocus
June 1, 2020
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Is Africa practicing better medicine than Europe and the United States on C19? https://bit.ly/3eCqMsR Interesting question?jerry
June 1, 2020
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RH7, the 100 mn BBL/day production potential for oil obtains, we see consequences of ill advised offshoring of strategic industries to geostrategic competitors and states with inherently poor governance systems. Dislocations are predictable, but temporary. Look at how oil fell into the $20's and even for a moment WTI futures went negative as it was cheaper to pay others to take it off one's hands than to try to store it. Oil is a key feedstock and Coal a key alternative. Fluctuations will settle out. KF PS: Protocols with appropriate doses have been on the table from several sources, backed up by decades of experience. They are similar in range.kairosfocus
June 1, 2020
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The coronavirus pandemic has had a major impact on industries around the world, including Active Pharmaceutical Ingredients (API) and finished drug formulation. Due to supply shortages for COVID drugs such as Hydroxychloroquine (HQQ), Paracetamol, and Acyclovir, there is a 1,000 – 2,000 fold increased demand across global regions, according to Beroe Inc, a procurement intelligence firm. The U.S. accounts for 28 percent of the FDA registered API manufacturing facilities, and is completely functional and intact as of today. India and China jointly account for 31 percent of FDA registered API manufacturing facilities, but supply more than 80-90 percent of raw materials to developed nations like the U.S. and those in Europe. The U.S. and European nations are now focussing on reshaping the pharmaceutical supply chain, understanding their reliance on the Asian Pacific countries for the pharmaceutical raw materials and generic drugs. On an average, API prices have increased by 10-15 percent since the COVID pandemic began, however, in some cases, the increase has been more than 50 percent. The highest price hike is visible for Hydroxychloroquine which has had a hike of 600 percent, followed by Nimesulide with a hike of 185 percent, and Azithromycin with 96 percent. Other API price hikes include Ornidazole with a 73 percent hike, Paracetamol with 62 percent, Montelukast sodium with 52 percent, and Penicillin with a price hike of 40 percent. https://www.ptcommunity.com/wire/coronavirus-leads-multi-fold-increase-api-demand-beroe-analysisrhampton7
May 31, 2020
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If we were to give everyone HCT to prevent Coronavirus, it would far exceed current manufacturing capacity, which is mostly in India and China. I see no indication that this is happening, other than China upping the price of raw materials by 4000% !rhampton7
May 31, 2020
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Of note, the current worldwide need of 300 metric ton for HCQ was spread out across an entire year and was met steadily, mostly for chronic diseases. The COVID-19 demand, however, is an immediate surge. For example, if 2% of the US population needs treatment, 40 metric tons of HCQ would be need urgently. If, however, 20% of the US population needs to be treated, 400 metric tons of HCQ would be needed in weeks. Globally, 2% treatment rate means a requirement of 1000 metric tons of the drug in weeks, or 3 times the current world annual production capacity. Can this be me withi reasonabls time? Under extreme circumstances, such as a global demand surge for 10,000 metric tons of HCQ to treat over up to 20% of the world population as illustrated on the far right column in Table 1, vitally necessary is the close international collaboration between global governments, pharmaceutical manufacturers and regulatory agencies in order to mobilize and coordinate worldwide resources to meet the demand. Lessons can be learned from the success of penicillin production scaled up from milligrams to metric tons within two years during the World War II. This was achieved with leadership for being accountable, courage for taking risks, can-do attitude and ingenuity from scientists and engineers, and commitment of the governments and enthusiastic participation by more than 20 private companies. In conclusion, we remain cautiously optimistic with the global manufacturing capability to ramp up production, meeting the demand for HCQ should it be proven efficacious by randomized clinical trials. Rationing and allocation to focus resources on the truly needy should be vigorously implemented to address the current shortage before large supply catches up. Considering that there is significant lead time to ramp up production at this scale, cost of API production is relatively small, staring materials are readily available, and the potential benefits and probability of HCQ be eventually proven efficacious [11] to help patients inflicted with COVID-19, immediate ramping up of production at risk as a contingency before definitive clinical trials conclude appears to be justifiable. https://www.sciencedirect.com/science/article/pii/S2590098620300233rhampton7
May 31, 2020
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RH7, oil is still there, refineries are still there, chemical process units, piping, instrumentation and engineers are still there, stainless steel etc are still there. I gather a decent pharmacist possibly could synthesise HCQ in his back room bench, though that would need confirmation. KFkairosfocus
May 31, 2020
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Russia has confirmed 9,268 new COVID-19 cases in the past 24 hours, raising its total tally to 405,843, its coronavirus response center said in a statement Sunday. The death toll increased by 138 to 4,693, while 171,883 people have recovered, including 4,414 over the last 24 hours, according to the statement. Moscow, the country's worst-hit region, reported 2,595 new confirmed COVID-19 cases in the last 24 hours, taking its total to 180,791. As of Saturday, 305,384 people were under medical observation, and more than 10.6 million lab tests for COVID-19 have been conducted nationwide, Russia's consumer rights and human well-being watchdog Rospotrebnadzor said in a statement Sunday. https://www.timesnownews.com/international/article/covid-19-pandemic-russia-sees-record-rise-as-coronavirus-cases-surge-past/599516rhampton7
May 31, 2020
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KF, note that this study establishes dosages within a treatment plan. That’s just one of the purposes of the RCT. Unfortunately there is not enough HCT to put everyone not infected on such a regimen.rhampton7
May 31, 2020
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I placed a call onto my friend Dr. Mohammed Bourdi, a very well established toxicologist who has about 27 years of experience under his belt with the prestigious National Institute of Health (NIH) and who has recently embarked on a new journey with a pharmaceutical company out of Maryland.
When. there is no alternative treatment, the control group are the rest of the infected world receiving no treatment. He seems to be ignorant of what is necessary to assess the effect of a treatment. We have lots of information for the no treatment control group. This doctor's assessment is meaningless at best. Left out from the article referenced by RHampton's brief excerpt is
I am still hesitant to dismiss the sweeping success of Hydroxychloroquine in Morocco and other countries as a pure stroke of luck. Moroccan Minister of Health, Khalid Ait Taleb put out a statement distancing Morocco from the finding of Lancet Journal and the official position of the WHO cautioning against the use of Hydroxychloroquine.
And a lot of other positive news on HCQ. Of course this is Morocco and from our superior arrogance who are we to look to Morocco for advice. They and several other countries have had incredibly good success with the drug that WHO once said was harmless but now kills when used for C19.jerry
May 31, 2020
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Finally, some solid evidence: As many as 80% of the health care workers (HCWs) on six or more prophylactic doses of the anti-malarial drug hydroxychloroquine (HCQ) were not infected by Sars-CoV-2, the virus that causes the coronavirus disease (COvid-19), according to a new pre-print study by the Indian Council of Medical Research (ICMR) -- a finding that could establishing the prophylactic properties of the drug against Covid-19, even as several international studies have dismissed its utility as a therapeutic. The results are based on a case control study for which participants were randomly drawn from the countrywide Covid-19 testing data portal maintained by ICMR. The test results and contact details of health care workers (HCWs), diagnosed as positive (cases) or negative (controls) for Sars-CoV-2 using the reverse transcription-polymerase chain reaction (RT-PCR) test, were available from this database. “ The main conclusion that can be drawn after analyzing the data is that HCQ has beneficial effects in infection risk reduction from fourth dose onwards. The first loading dose of 800mg and then every week a dose of 400 mg for 4, 6 or more weeks as per your physician’s advice will help cut the risk of infection by 80% in healthcare workers who are not already sick,” says Dr Samiran Panda, director, ICMR-National AIDS Research Institute, the study co-author. https://www.hindustantimes.com/india-news/80-dip-in-infection-risk-for-health-staff-on-hcq-study/story-4Btz0DoDQtM0qacOCWZn7I.htmlrhampton7
May 31, 2020
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PS: I remind, from No 55 in the Dr Lozano thread. This is Kennedy School of Government at Harvard, with a professor and with a French doctoral graduate:
Observe:
Unleash the Data on COVID-19 By Maryaline Catillon and Richard Zeckhauser* Given the lethality of the COVID-19 pandemic, the urgent need is for actionable information directing care towards treatments offering higher probabilities of improving outcomes and preventing death. In normal times, randomized control trials (RCTs) would be the gold standard for determining whether innovative medical treatments are safe and effective. But with 1,500 Americans dying every day, these are hardly normal times. There is an urgent need for high quality studies based on real world experience, which has already accumulated for many thousands of patients. Dr. Anthony Fauci, the nation’s pandemic physician in chief, said that RCT results will not be available "for months". The disease will not wait. RCTs, which randomly assign patients to a treatment or a control group, are only ethically acceptable when the safety and performance of a treatment is unknown. When ample data exists, as now, that criterion is not met. Analyzing real world data on actual outcomes, when it exists in abundance, offers an alternative approach to learn almost immediately. Moreover, it avoids the ethical challenge of an RCT, given that available data could predict outcomes. Massive numbers of COVID-19 patients are currently being administered "unproven" drugs based on medical decisions made by doctors. Massive numbers are not receiving any such drugs. Thus, carefully designed case control studies could leverage differences between ongoing protocols at large hospital systems and detailed information from patients’ electronic medical records. That could determine whether widely employed hydroxychloroquine, with or without azithromycin, provides significant benefits, and at which stages to which patients, and could provide similar information on the risks it imposes. It could yield the same information about remdesivir, and about many other drug treatments currently in use. [--> sounds familiar? That's been a line of argument I have pointed to for weeks] For each patient, doctors strive to optimize treatment in the current, uncertain environment. These drug versus non-drug decisions constitute an ongoing large observational study, in which the allocation to treatment and control groups varies widely. The large numbers of patients treated eliminates concerns that random variation might lead to misleading results. Those large numbers also yield results by demographic, comorbidities, and stage of disease. Leveraging real world evidence is more acceptable ethically when extensive information is already available. As decision theorists who have studied the methodological quality of vast numbers of RCTs, we are enthusiasts for well-conducted RCTs. But delaying public health recommendations till RCTs are completed is not appropriate in the present circumstance. Imminent threats are enormous and widespread data is easily at hand. The outcomes of the thousands of individuals who have already received drug therapies on an ad hoc basis should inform practice now . . . . High quality case control studies based on thousands of cases, the silver standard we recommend, are immensely faster than RCTs. Recent articles in the world’s leading medical journals show that they consistently yield the same major findings. Experience with the recommendations of antiretroviral therapy (ART) for HIV provides an instructive warning. Even though 20 years of observational studies demonstrated its enormous benefits, the World Health Organization waited until 2015 and the publication of the first set of RCT results (which reached the same conclusions) to make a "treat all" recommendation. Many lives were lost as the world waited for its recommendation. COVID-19 presents its own example. Through late March, medical authorities recommended the general public not employ masks to protect against it. In early April, that all switched: masks became strongly recommended. No RCT supported this reversal; little evidence was mounted. Yet officials applauded, the public widely complied, and the world was better off.
Well conducted includes ethical criteria. Of course. But such is obviously at a discount today. And notice the by now familiar context: decision theory.
kairosfocus
May 31, 2020
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RH7, all you have established is how deeply a serious error of inductive warrant (thus of logic and epistemology both, with ethical import) has been entrenched. The decision theory results I have pointed to are not strange or even counter-intuitive; this is not like the motion of gyroscopes or quantum theory or relativity. The idea that common practice producing reliably unsatisfactory results can be responsibly challenged by an alternative that shows a better result consistently in a context where there is not the time for placebo controlled trials, and where there is a serious issue that one is giving sugar pills to people facing a fast moving damaging and too often fatal disease should not even be controversial as a way forward. The ethical challenges of placebo use i/l/o the first do no harm principle are well known. All of this is quite sad, but it is where we are today. KFkairosfocus
May 31, 2020
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Following is a transcript of Prime Minister Netanyahu’s remarks: As long as there is no vaccine for the virus, it will return and spread if we are not strict about being cautious. We are all called upon to continue adhering to the rules. When I say ‘we are all’ that includes me, my fellow ministers, MKs and it includes you – dear citizens of Israel. “The rules are simple: Maintain two meters’ distance. Wear masks in the public sphere. Wash your hands and maintain the rules of hygiene. “If we do not do this, there will be no choice but to go back to restrictions on the economy and in the public sphere. If we do this, we will be able to continue to open our economy, bring back jobs, restore growth and restore hope. “From now on, we will do three things in tandem: We will tighten the discipline regarding the corona rules that had loosened. We will encourage activity by businesses that respect this discipline and we will act against whoever does not strictly uphold the rules and thus endangers the health of us all.“ https://www.jewishpress.com/news/health-and-medicine/coronavirus/live-netanyahu-says-pandemic-in-israel-wont-be-over-till-we-have-a-vaccine-so-follow-the-rules-or-return-to-lockdown/2020/05/30/rhampton7
May 31, 2020
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All students and teachers at Jerusalem’s Gymnasia High School will enter quarantine for over a week after over 100 people there contracted COVID-19, in the largest concentrated outbreak of the virus since infections began to wane earlier this month. The outbreak at the school, plus a spread of cases that temporarily closed 17 other institutions around the country, has raised concerns of a potential second wave of the coronavirus pandemic. Despite the sharp increase in recent days in coronavirus infection rates focused on education institutions, cabinet ministers decided against a sweeping closure of schools during an overnight meeting. Prime Minister Benjamin Netanyahu, in a Saturday night press briefing, also said new restrictions could be introduced if the number of cases pick up. The next few days will be a “test,” he said. https://www.timesofisrael.com/as-school-concerns-mount-all-from-jerusalem-high-school-hit-by-virus-isolated/rhampton7
May 31, 2020
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Turkey’s Science Board is examining the possible effects of hydroxychloroquine on COVID-19 patients in the face of claims that the drug may cause some complications, Professor Ahmet Demircan, a member of the board, has said “ This is a new disease and when the outbreak began, hydroxychloroquine was the only drug available. It has been long used in malaria treatment. Assertions against this particular drug have not yet been scientifically substantiated. It is too early to draw conclusions as more scientific research is needed,” according to Demircan, who is also the rector of Gazi University in Ankara. The science body is collecting data regarding the drug’s side effects from the World Health Organization (WHO) as well as across Turkey, he said. “We will have a clearer picture after the examination of those data. Depending on the findings, we will either recommend the use of the drug in fewer doses or replace it with alternative drugs,” Demircan said. https://www.hurriyetdailynews.com/science-board-looks-at-use-of-hydroxychloroquine-in-turkeys-covid-19-treatment-155216rhampton7
May 31, 2020
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The Indian Council of Medical Research (ICMR), the country’s apex medical research body, is reviewing the benefits of drugs ivermectin and doxycycline as potential therapy for Covid-19. The combination of these two drugs has been hailed by doctors in Bangladesh for yielding “astounding results”. “We are closely studying the drug ivermectin and its possible efficacy against Covid-19. We have used antibiotic doxycycline for long and its mechanism of working is fairly clear. However, the former needs to be studied more closely,” Nivedita Gupta, senior scientist at ICMR, told ThePrint. Out of 60 COVID-19 patients, all recovered as the combination of the two drugs were applied”, Professor Dr Md Tarek Alam, the head of medicine department at the Bangladesh Medical College Hospital (BMCH) told news agency PTI. The Bangladeshi doctors claimed that the efficacy of the ivermectin-doxycycline drug combination is quite high and it has helped in the recovery of patients afflicted with Covid-19 within four days. They also claimed that “there were no side effects” of this treatment. https://theprint.in/health/icmr-to-review-wonder-drug-combo-used-to-treat-covid-patients-in-bangladesh/432987/rhampton7
May 31, 2020
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Dr. Raoult’s unorthodox approach to medicine has made him an easy target by those who see any sort of deviation from the process as plain quackery. Dr. Raoult has been called a fraud despite the fact that some of the results he has been able to produce remain hard to refute. I placed a call onto my friend Dr. Mohammed Bourdi, a very well established toxicologist who has about 27 years of experience under his belt with the prestigious National Institute of Health (NIH) and who has recently embarked on a new journey with a pharmaceutical company out of Maryland. My inquiry was blunt, unequivocal, and coming from someone with zero medical background. If Dr. Raoult was such a hack, why is there so much pushback against him? Why don’t they let him dig his own demise? Dr. Bourdi insists that proper protocol was not followed and no matter what kind of desired results Dr. Raoult keeps churning out, a single outlier is enough to send his entire scientific edifice into a tailspin. He explains that as long as no control groups are tested and no substantial clinical testing is run at a massive scale, a good outcome should be chalked up as no more than a feel good story that can’t rise to the level of scientific data. https://www.moroccoworldnews.com/2020/05/304134/hydroxycloroquine-debate-the-tragedy-of-cure-and-greed/rhampton7
May 31, 2020
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RH7, at least, someone is beginning to notice the stitch in time principle. KFkairosfocus
May 31, 2020
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Jerry, yes. What do you think is happening as more and more people see that they cannot trust the media, the experts, the pundits, the big names to get things right or to be fair or to be prudent? Even with things directly in hand, here and now with lives on the line? KFkairosfocus
May 31, 2020
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South Dakota is going forward with plans to test an anti-malaria drug in small doses to prevent COVID-19, Gov. Kristi Noem announced Thursday. Noem enlisted Dr. Allison Suttle, Sanford Health’s chief medical officer, to explain that this trial is different. Instead of administering the drug to people with serious cases of COVID-19, it will give smaller doses to people who have been exposed to the coronavirus in the hope it helps their immune system ward off the virus. Sanford is no longer recommending people with serious cases of COVID-19 take the drug. https://apnews.com/b3b17419137310e37aded9d2f9400258rhampton7
May 31, 2020
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This is what we are up against.
The resistance to the truth about HCQ in the press is just a replay of past hoaxes in the last 4 years. When one gets exposed, another pops up. HCQ is just the latest. They don't care if people die, it is just a statistic to them in the fight against what they do not like. The interesting question at the bottom of all this hostility to the truth is just what is it they don't like and why they don't like it. The surface of it appears here to resistance to ID or anything else proposed by it and its defenders. It is not just here but everywhere in our current Western society. This site is like a magnet that draws the flies to honey but it is only a very small dose of honey so only a few appear but they are representative of the whole.jerry
May 31, 2020
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F/N: I mark up a money shot paragraph from the VF article, which exposes many layers of what is going on: >>A growing body of clinical studies>> -- these focus on the phase far down the descending arm of the U, as will come out momentarily -- this is irrelevant to high up, in early phases, as was already noted. >> indicates that hydroxychloroquine is ineffective in treating COVID-19>> -- using Gold Standard fallacy to dismiss the misframing on timing and the evidence of thousands of cases regarding early treatment >> and may actually increase mortality.>> -- the very opposite of evidence on what happens early in the descending arm, ie we see suppression of the stitch in time issue >> The World Health Organization, the National Institutes of Health, the FDA, and the pharmaceutical company Sanofi, which sells hydroxychloroquine under the brand name Plaquenil, have all issued guidelines cautioning against the kind of early, prophylactic use of the drug that Trump has hyped>> -- the misframing at the pivot of the issue is dismissed based on appeal to authority, authority being used to lock out what works, early treatment; based on what happens when things have gone into serious damage that is then hard to treat successfully with anything. >> and Zelenko advocates.>> --pray thee, tell us WHY does Dr Zelenko advocate that early treatment under a precise, tailored, physician-supervised protocol may be more effective than trying to come back from serious damage to the vitals by a fast moving disease? -- this is setting up and knocking over a strawman under weight of presumed but misframed authority. >> On Friday a retrospective study of 96,000 COVID-19 patients on six continents, published in the medical journal The Lancet, >> -- the manifestly deeply flawed study (by misframing when treatments begin . . . too late) I commented on point by point here: https://uncommondescent.com/medicine/doctor-ivette-lozano-from-dallas-texas-on-treating-patients-with-hcq-cocktails/#comment-702509 >>found that hospitalized patients >> -- smoking gun on being too far down the descending arm of the U, where Dr Raoult's 500+ CT scans show lung lesions are likely already there when "mild" symptoms begin -- that in turn suggests other damage to other organs and systems likely to be attacked, including the heart. -- this is a race to beat advancing damage >> treated with hydroxychloroquine and an antibiotic—part of the drug combination Zelenko has plugged—were 45% likelier to die.>> -- Of course, fails to address the issue that the disease itself attacks the cardiovascular system and is likely to do damage to the heart all by itself, fails to recognise variations such as doxycycline, fails to look at the report in the NY press that Ivermectin added to the cocktail may help reach down lower on the descending arm to pull up patients otherwise in serious trouble. This is a capital example of irresponsible journalistic bias building on serious errors of method in investigation by those responsible to get things right in a life and death situation for the world. This is what we are up against. KFkairosfocus
May 31, 2020
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EG, First, (very) early spread feeds exponential growth which then propagates in an avalanche; there is a saying about barn doors and bolted horses. And, Canada is not the focus of my point, the general neighbourhood of the Hudson Estuary is. A specific local part of a well known federal entity, and not the confederation based at Turtle Bay on a famous island. KFkairosfocus
May 31, 2020
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I love how Acartia Eddie talks from its position of non-authority as if it is fact. And how it ignores facts that contradict its non-authority...ET
May 31, 2020
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