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‘Junk DNA’

Another job for “junk DNA”: Killing cancer in blind mole rats

Researcher: “The paper describes an important new mechanistic insight into the way one can trigger inflammatory signals in cancer cells to either kill them directly or make them vulnerable to cancer-killing therapies,” says cancer biologist Stephen Baylin of Johns Hopkins School of Medicine, who was not involved in the research. “The importance of it is really quite profound.” Read More ›

Researchers: “Junk DNA” plays a key role in speciation

At Phys.org: When the researchers deleted a protein called Prod that binds to a specific satellite DNA sequence in the fruit fly Drosophila melanogaster, the flies' chromosomes scattered outside of the nucleus into tiny globs of cellular material called micronuclei, and the flies died. "But we realized at this point that this [piece of] satellite DNA that was bound by the Prod protein was completely missing in the nearest relatives of Drosophila melanogaster," Jagannathan said. "It completely doesn't exist. So that's an interesting little problem." Read More ›

ENCODE foe Dan Graur isn’t sure if Jesus existed

Wow. Dr. Graur should get out more. Only crackpots argue that Jesus did not exist... There is less evidence for the existence of Socrates but no one gets all skeptical about him. Interesting responses. Read More ›

The non-coding human genome is being filled in

At Axios: Why it matters: The bulk of the human genome is noncoding regions, some of which play an important role in how genes are expressed. New tools are allowing scientists to test exactly how these elements — once called "junk DNA" — work, which could lead to new drug targets. Read More ›

ID theorists were right about junk DNA. Now here is an ID prediction about CRISPR gene editing

William Dembski: The big question, then, is whether CRISPR gene editing will allow for huge improvements of human and other animal forms via genetic enhancements. My prediction is that it won’t. Specifically, I predict that attempted enhancements of the human germ line using CRISPR gene editing will (1) quickly hit an “enhancement boundary” beyond which enhancements are no longer feasible and (2) prove self-canceling in the sense that intended benefits will be undone by unintended deficits. Read More ›

At Evolution News: “Junk DNA” needed for limb formation

At Nature: “A new study in Nature underscores just how important noncoding DNA can be for human development. The authors show that deletions in a noncoding region of DNA on chromosome 2 cause severe congenital limb abnormalities. This is the first time a human disease has been definitively linked to mutations in noncoding DNA, says lead author Stefan Mundlos, head of the development and disease research group at the Max Planck Institute for Molecular Genetics in Berlin, Germany.” Read More ›

Larry Moran’s new book sounds like a scorcher

He thinks there must be something “seriously wrong” with science if people keep looking for new functions for junk DNA. What’s “wrong,” so far as the rest of us can see, is that researchers keep finding new functions that formerly-junk DNA performs, so they keep looking. For the same reasons as fisherfolk return to the well-stocked lake. Read More ›

Project to map 70,000 vertebrate genomes already turning up more bad news for “junk DNA”

Also: “The work revealed that the last surviving kākāpō population, isolated on an island off New Zealand for the last 10,000 years, has somehow purged deleterious mutations, despite the species' low genetic diversity.” Hmm. Read More ›

Rob Sheldon on Larry Moran and the junk DNA

Sheldon: If I recall correctly, the original definition of "functional" was whether that piece of DNA was turned into a protein, which depended on finding a "start" and a "stop" codon. The Human Genome Project reported that some 90% of the human genome didn't have these "start/stop" features, and hence was "non-functional". ["Non-functional" underwent considerable revision later.] Read More ›

Discovery of useful “junk DNA” “has outstripped the discovery of protein-coding genes by a factor of five…

At Nature: "Likewise, the number of publications about such elements also grew in the period covered by our data set. For example, there are thousands of papers on non-coding RNAs, which regulate gene expression." We also learn the possible origin of the term "junk DNA." Read More ›

Did beliefs about junk DNA hinder the Human Genome Project?

But wasn’t a vast pile of junk DNA supposed to be one of the Great Proofs of Darwinism in the DNA? Funny, no one suggests that the constant diminution of the pile is evidence against the theory that its presence was supposed to be evidence for. Now why do you think that might be? Read More ›

The human genome at 20. We have some answers but way more questions now.

At The Conversation on junk DNA: Bewilderingly, scientists found that the non-coding genome was actually responsible for the majority of information that impacted disease development in humans. Such findings have made it clear that the non-coding genome is actually far more important than previously thought. Read More ›