In the 20th century, a powerful confluence of evidence emerged that essentially eviscerated the creative power of Darwinian mechanisms. This is not hard to figure out.
The most “simple” cell is a marvel of functionally integrated information-processing technology. Those who propose that the Darwinian mechanisms of random errors filtered by natural selection explain all of life are living in an era gone by, a time when it was thought that the foundation of life was chemistry, physics, time, and chance.
The fossil record is a grand and ever-persistent testimony that Darwin was wrong about gradualism. Simple logic, trivial combinatoric mathematical analysis, and the monstrous problems presented by the likelihood of functional, naturally-selectable intermediates, present overwhelming evidence that Darwinian mechanisms are on their deathbed in terms of their explanatory power for anything but the utterly trivial.
In a sense I feel sorry for Darwinian fundamentalists. It must be depressing to realize that one has wasted his life defending a transparently ephemeral goal that has little to do with reality, nothing to do with real scientific investigation, and that has nothing whatsoever to recommend itself besides philosophical nihilism.