Also known as the information enigma re the origin of life.
Equally problematic, even if building blocks naturally joined together and never degraded, no natural process could order the monomers in the correct sequence to contain useful biological information. Each of these challenges represents an insurmountable barrier to any biologically useful macromolecule ever appearing and migrating into the staging ground for life’s origin.
Brian Miller, “James Tour Video Series on the Origin of Life — Properly Combining Building Blocks” at Evolution News and Science Today