Cosmologist Paul Davies won an award last year for a book that was an attempt that left “more questions than clean-cut answers” (Physics World):
How about, for example:
➤ Information: Unlike matter and energy, information is immaterial. “ It exists, among other things, as a relationship between realized and unrealized possibilities.” Information governs.
➤ Origin of life: Life forms are overwhelmingly full of information and theories as to how that got started are really not very good. “There are few bigger — or harder — questions to tackle in science than the question of how life arose.” (Quanta, 2015) Nothing has changed since then.
➤ Consciousness. We are, for example, told that:
To discover what makes us self-aware, researchers from around the world are going head-to-head in a grand competition to determine where consciousness really comes from…News, “But do hidden webs of information really solve life’s mysteries?” at Mind Matters News
All the real problems occur at the boundaries, which means that they are not contained by anything.