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epigenetic change as reversible

Closing in on how early life stress changes epigenetic markers

The good news from this mouse study is that if epigenetic stress is recognized, it can be reversed. That means, presumably, that it won’t be passed on: In a study published March 15 in Nature Neuroscience, researchers found that early-life stress in mice induces epigenetic changes in a particular type of neuron, which in turn make the animals more prone to stress later in life. Using a drug that inhibits an enzyme that adds epigenetic marks to histones, they also show that the latent effects of early-life stress can be reversed. “It is a wonderful paper because it is really advancing our ability to understand how events that happen early in life leave enduring signatures in the brain so that Read More ›