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Squid self-edit their genomes

Open access: Abstract: In eukaryotic cells, with the exception of the specialized genomes of mitochondria and plastids, all genetic information is sequestered within the nucleus. This arrangement imposes constraints on how the information can be tailored for different cellular regions, particularly in cells with complex morphologies like neurons. Although messenger RNAs (mRNAs), and the proteins that they encode, can be differentially sorted between cellular regions, the information itself does not change. RNA editing by adenosine deamination can alter the genome’s blueprint by recoding mRNAs; however, this process too is thought to be restricted to the nucleus. In this work, we show that ADAR2 (adenosine deaminase that acts on RNA), an RNA editing enzyme, is expressed outside of the nucleus in Read More ›

Deemed “officially weirder”: Octopuses edit their RNA in response to environment

Well, first, we don’t really know for sure that no other life form does this. Maybe others do and we haven’t caught up to them yet. It would be easier to place in a context if we had a group to study rather than an outlier. Read More ›