Why Don’t Globular Proteins Knot UP?
Here’s an abstract from the Journal of Physics tackling the issue of “knottiness” in polymeric chains. Notice that the authors were able to “design” sequences which either knotted up all the time or did not knot, using polymer lengths of 500. Now, I wonder what the odds of arriving at a sequence which does “not knot” randomly? (1 in 20^500) And, if you couldn’t get beyond the knotting up of a protein molecule, then how could life continue? Everyday experience shows that strings easily knot. Preventing this requires careful folding or winding when stowing away. Molecular ropes, like polymer chains, can suffer the same fate, but that is not true for biopolymers like proteins and DNA; despite their complex folded Read More ›