Can medical research be brought back from rigor mortis?
A review of Richard F. Harris Rigor Mortis: How Sloppy Science Creates Worthless Cures, Crushes Hope, and Wastes Billions by Marcus Munafò at Nature: Harris introduces us to the growing field of metascience — the scientific study of science itself — and some of those working in it. These reproducibility firefighters are providing answers to such empirical questions, and identifying interventions. Robert Kaplan and Veronica Irvin at the US National Institutes of Health (NIH) showed that when the National Heart, Lung, and Blood Institute required preregistration of primary outcomes (the main outcome against which success should be judged) in clinical trials, the proportion of studies reporting a benefit fell from 57% to 8%. That’s the good news. The bad news Read More ›