Human brain cells live long but acquire thousands of mutations along the way
From Ruth Williams at The Scientist: Two studies in Science today (December 7)—one that focuses on prenatal development in humans, the other on infancy to old age—provide insights into the extent of DNA sequence errors that the average human brain cell accumulates over a lifetime. Together, they reveal that mutations become more common as fetuses develop, and over a lifetime a person may rack up more than 2,000 mutations per cell. … Within the now burgeoning field of somatic mutation analyses, the brain is a particular area of interest. That’s because unlike organs such as the skin and gut where cells are replaced daily, the brain’s neurons, once established in the fetus, for the most part stick around for life. Read More ›