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Many thanks to Gordon Davisson and Joe Felsenstein for review and criticism of my UD article

I previously highlighted the work of Jean Claude Perez in my Vodka! essay. I had encountered Perez work in my google searches related to the 3-base periodicity pattern in DNA. The 3-base pattern seems widely acknowledged in the literature as On the origin of three base periodicity in genomes. Genomes of almost all organisms have been found to exhibit several periodicities, the most prominent one is the three base periodicity. It is more pronounced in the gene coding regions and has been exploited to identify the segments of a genome that code for a protein. The reason for this three base periodicity in the gene-coding region has been attributed to inhomogeneous nucleotide compositions in the three codon positions. However, this Read More ›

Non Randomness of DNA as a whole

Stretches of DNA that code for proteins are considered non-random, but what about DNA as a whole? DNA Densely Packed without Knots “‘We’ve long known that on a small scale, DNA is a double helix…But if the double helix didn’t fold further, the genome in each cell would be two meters long. Scientists have not really understood how the double helix folds to fit into the nucleus of a human cell, which is only about a hundredth of a millimeter in diameter…’ “The researchers report two striking findings. First, the human genome is organized into two separate compartments, keeping active genes separate and accessible while sequestering unused DNA in a denser storage compartment. Chromosomes snake in and out of the Read More ›