John Sanford gives lecture at NIH on mutations and human health

The upshot, neo-Darwinism is as probable as a flat earth. jstanley01

Sanford's book is a coldly sobering antidote to the manically surreal optimism of the "fitness always increases" variety. ScuzzaMan

aarceng, Dr. Paul Giem did a chapter by chapter review of the book here:

Biological Information: The Book 10-04-2014 by Paul Giem https://www.youtube.com/watch?v=vg_xp0dRUdM&index=1&list=PLHDSWJBW3DNUUhiC9VwPnhl-ymuObyTWJ

Here is the entire book:

Biological Information New Perspectives Proceedings of the Symposium - July 2013 https://www.worldscientific.com/doi/pdf/10.1142/8818

And here it is in a chapter by chapter format

Biological Information New Perspectives Proceedings of the Symposium - July 2013 https://www.worldscientific.com/worldscibooks/10.1142/8818#t=toc

One of my favorite chapters out of many favorites,,,

Multiple Overlapping Genetic Codes Profoundly Reduce the Probability of Beneficial Mutation George Montañez1, Robert J. Marks II2, Jorge Fernandez3 and John C. Sanford Excerpt: Excerpt: In the last decade, we have discovered still another aspect of the multi- dimensional genome. We now know that DNA sequences are typically “ poly-functional” [38]. Trifanov previously had described at least 12 genetic codes that any given nucleotide can contribute to [39,40], and showed that a given base-pair can contribute to multiple overlapping codes simultaneously. The first evidence of overlapping protein-coding sequences in viruses caused quite a stir, but since then it has become recognized as typical. According to Kapronov et al., “it is not unusual that a single base-pair can be part of an intricate network of multiple isoforms of overlapping sense and antisense transcripts, the majority of which are unannotated” [41]. The ENCODE project [42] has confirmed that this phenomenon is ubiquitous in higher genomes, wherein a given DNA sequence routinely encodes multiple overlapping messages, meaning that a single nucleotide can contribute to two or more genetic codes. Most recently, Itzkovitz et al. analyzed protein coding regions of 700 species, and showed that virtually all forms of life have extensive overlapping information in their genomes [43]. 38. Sanford J (2008) Genetic Entropy and the Mystery of the Genome. FMS Publications, NY. Pages 131–142. 39. Trifonov EN (1989) Multiple codes of nucleotide sequences. Bull of Mathematical Biology 51:417–432. 40. Trifanov EN (1997) Genetic sequences as products of compression by inclusive superposition of many codes. Mol Biol 31:647–654. 41. Kapranov P, et al (2005) Examples of complex architecture of the human transcriptome revealed by RACE and high density tiling arrays. Genome Res 15:987–997. 42. Birney E, et al (2007) Encode Project Consortium: Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature 447:799–816. 43. Itzkovitz S, Hodis E, Sega E (2010) Overlapping codes within protein-coding sequences. Genome Res. 20:1582–1589. Conclusions: Our analysis confirms mathematically what would seem intuitively obvious - multiple overlapping codes within the genome must radically change our expectations regarding the rate of beneficial mutations. As the number of overlapping codes increases, the rate of potential beneficial mutation decreases exponentially, quickly approaching zero. Therefore the new evidence for ubiquitous overlapping codes in higher genomes strongly indicates that beneficial mutations should be extremely rare. This evidence combined with increasing evidence that biological systems are highly optimized, and evidence that only relatively high-impact beneficial mutations can be effectively amplified by natural selection, lead us to conclude that mutations which are both selectable and unambiguously beneficial must be vanishingly rare. This conclusion raises serious questions. How might such vanishingly rare beneficial mutations ever be sufficient for genome building? How might genetic degeneration ever be averted, given the continuous accumulation of low impact deleterious mutations? https://www.worldscientific.com/doi/pdf/10.1142/9789814508728_0006

And for a bonus, here is link to articles by Dr. Sanford

Dr. John Sanford - Links to Selected Papers http://www.logosresearchassociates.org/john-sanford

bornagain77

Biological Information only $109 on Amazon. Let me know when the e-book comes out. aarceng

The dream book would be one co-authored by both Sanford and Behe. Their work intersects on many levels. But overall, Sanford is more 'big picture' oriented whereas Behe tends to get into the fine molecular details of what is going on. Yet both come to the same general conclusion which is, basically, "it's down not up", i.e. devolution.

GENETIC ENTROPY - It's Down NOT Up... Sanford http://www.geneticentropy.org/ Darwin Devolves — Preorder Behe’s New Book; Plus Video Course on Intelligent Design! - Nov. 14, 2018 https://evolutionnews.org/2018/11/darwin-devolves-preorder-behes-new-book-plus-video-course-on-intelligent-design/

bornagain77