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P threshold values often likely false?

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From John Ioannidis at the Journal of the American Medical Association:

vPalues and accompanying methods of statistical significance testing are creating challenges in biomedical science and other disciplines. The vast majority (96%) of articles that report P values in the abstract, full text, or both include some values of .05 or less. However, many of the claims that these reports highlight are likely false. Recognizing the major importance of the statistical significance conundrum, the American Statistical Association (ASA) published3 a statement on P values in 2016. More.

See also: P-values: Scientists slam proposal to raise threshold for statistically significant findings

and

Ioannidis again on misleading meta-analyses