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Human genes use a dual strategy of “prevention and cure” to deal with a type of error

From “Preventing Dangerous Nonsense in Human Gene Expression” (ScienceDaily, Oct. 14, 2011), we learn: Human genes are preferentially encoded by codons that are less likely to be mistranscribed (or “misread”) into a STOP codon. This finding by Brian Cusack and colleagues from the Max Planck Institute for Molecular Genetics in Berlin and the CNRS in Lyon and Paris is published in the open-access journal PLoS Genetics. In biological systems, mistakes are made because the cellular machinery is complex and error prone. The errors made in copying DNA for transmission to offspring (genetic mutations) have so far been the primary focus of molecular evolution. But errors are much more frequent in the day-to-day task of gene expression, for example in the Read More ›

Lost manuscripts, recovered after exhaustive efforts, establish Archimedes as the founder of combinatorics

In “Walters researchers decode the secrets of the Archimedes Palimpsest” Baltimore Sun, October 18, 2011), Mary Carole McCauley reports on the massive reconstruction job that has made available to us, after two millennia, the lost writings of the great, ancient Greek mathematician, Archimedes. It’s unfortunate that many know him only as the ancient Greek cartoon figure running naked and dripping through the streets shouting Eureka!, the bath attendant in hot pursuit. Archimedes’ legacy extends to mathematical fields as diverse as calculus and computer science. He made groundbreaking discoveries in hydrostatics, which measures the pressure exerted by liquids because of gravity. He invented the catapult, the battering ram, pulleys and siege machines. He was the first person to explain mathematically how Read More ›