Experimenters have recently found that genes–whereby they mean particular sequences of DNA–can “find” one another without the intervention of proteins or other factors. It appears to be strictly an effect caused by electrical charges along the DNA strand; the longer the ‘gene’ (that is, sequence length), the greater theapparent ease in ‘finding’ one another. The experimenters feel that this finding is a help for figuring out what happens during homologous recombination.
Here’s part of what they say: The researchers observed the behaviour of fluorescently tagged DNA molecules in a pure solution. They found that DNA molecules with identical patterns of chemical bases were approximately twice as likely to gather together than DNA molecules with different sequences.
Professor Alexei Kornyshev from Imperial College London, one of the study’s authors, explains the significance of the team’s results: ‘Seeing these identical DNA molecules seeking each other out in a crowd, without any external help, is very exciting indeed. This could provide a driving force for similar genes to begin the complex process of recombination without the help of proteins or other biological factors. . . .’
The article from ScienceDaily is here.
I have an OOL question: This study strongly suggests that similar DNA sequences have a preferential attraction for one another. And the longer the similar sequence, the greater the attraction. If that is the case, then, if a particular ‘gene’ began to ‘replicate’, wouldn’t the replicated ‘genes’ congeal together?
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