New Axe paper at BIO-Complexity: The Limits of Complex Adaptation
Available here. Axe’s analysis was motivated in part by the recent flurry of papers dealing with the problem of the waiting time for multiple independent mutations. Here is Doug’s abstract: To explain life’s current level of complexity, we must first explain genetic innovation. Recognition of this fact has generated interest in the evolutionary feasibility of complex adaptations–adaptations requiring multiple mutations, with all intermediates being non-adaptive. Intuitively, one expects the waiting time for arrival and fixation of these adaptations to have exponential dependence on d, the number of specific base changes they require. Counter to this expectation, Lynch and Abegg have recently concluded that in the case of selectively neutral intermediates, the waiting time becomes independent of d as d becomes Read More ›