Central Dogma revisited
This new paper by James Shapiro may be of interest . In it he elaborates on the central dogma of molecular biology. It has become very complex since the old “one gene one protein and all the rest is junk” days. Here is the summary table. Conventional expression of the Central Dogma of Molecule Biology: (DNA ==>2X DNA) ==> RNA ==> Protein ==> Phenotype Contemporary statements of molecular information transfer in cell: 1. DNA + 0 ==> 0 2. DNA + Protein + ncRNA ==> Chromatin 3. Chromatin + Protein + ncRNA ==> DNA replication, chromatin maintenance/reconstitution 4. Protein + RNA + lipids + small molecules ==> Signal transduction 5. Chromatin + Protein + signals ==> RNA (primary transcript) 6. RNA Read More ›