Human genes use a dual strategy of “prevention and cure” to deal with a type of error
From “Preventing Dangerous Nonsense in Human Gene Expression” (ScienceDaily, Oct. 14, 2011), we learn: Human genes are preferentially encoded by codons that are less likely to be mistranscribed (or “misread”) into a STOP codon. This finding by Brian Cusack and colleagues from the Max Planck Institute for Molecular Genetics in Berlin and the CNRS in Lyon and Paris is published in the open-access journal PLoS Genetics. In biological systems, mistakes are made because the cellular machinery is complex and error prone. The errors made in copying DNA for transmission to offspring (genetic mutations) have so far been the primary focus of molecular evolution. But errors are much more frequent in the day-to-day task of gene expression, for example in the Read More ›