Is functional information in DNA always conserved? (Part one)
Conservation of sequence in the course of natural history has always been considered a sign of function. But does function always coincide with sequence conservation? And are there other important aspects which must be considered? This topic has been discussed recently with some passion here, so I will dedicate a series of two posts to it, in the hope that we can base our discussions on reliable data. I apologize in advance if some of the following discussion is necessarily rather technical. In general, in evolutionary analysis, conservation is considered a sign of function. Protein coding genes which are more strictly conserved in the course of time are usually considered as having greater functional constraint than those genes which change more. The Read More ›