News

That seems to depend on who you read: Last year in the journal Science, a research review concluded that the chytrid fungus caused the decline of at least 501 amphibian species, of which 90 have gone extinct. That paper suggested that species losses due to the chytrid fungus are “orders of magnitude greater than for other high-profile wildlife pathogens.” But a recent reanalysis led by University of California, Berkeley, researchers found that the paper’s main conclusions lack evidence and are unreproducible. In a Comment published online March 19th in Science, the group conducting the reanalysis — including lead authors Max Lambert and Molly Womack, who are postdocs in the lab of professor Erica Rosenblum in the Department of Environmental Science, Read More ›

Open access: Abstract: In eukaryotic cells, with the exception of the specialized genomes of mitochondria and plastids, all genetic information is sequestered within the nucleus. This arrangement imposes constraints on how the information can be tailored for different cellular regions, particularly in cells with complex morphologies like neurons. Although messenger RNAs (mRNAs), and the proteins that they encode, can be differentially sorted between cellular regions, the information itself does not change. RNA editing by adenosine deamination can alter the genome’s blueprint by recoding mRNAs; however, this process too is thought to be restricted to the nucleus. In this work, we show that ADAR2 (adenosine deaminase that acts on RNA), an RNA editing enzyme, is expressed outside of the nucleus in Read More ›